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Cerebellar localisation

A 61-year-old man has a three-week history of clumsiness. On examination the finger-to-nose test shows a coarse tremor that worsens as the finger approaches the target, and rapid alternating movements are irregular, both confined to the right arm. He walks steadily and can stand with his feet together. Where is the lesion?

Explanation

Key fact
The cerebellum acts on its own side. Limb signs are ipsilateral; midline structures give truncal, not limb, ataxia.

Right cerebellar hemisphere. Intention tremor and dysdiadochokinesia in the right arm, with a normal gait, localise to the right hemisphere.

Why

The hemispheres coordinate the limbs; the vermis coordinates trunk and gait.

Normal walking and normal standing therefore put the vermis in the clear.

Signs are confined to one arm, so the lesion is one hemisphere.

Cerebellar output crosses twice - once in the superior peduncle, once in the corticospinal decussation.

Two crossings cancel, so the effect appears on the same side as the lesion.

Crosses twice, so it does not cross at all

The cerebellum from behind with a lesion in one hemisphere and a narrow grey vermis between, and a pathway marked with two crossings ending in the arm on the same side as the lesion

Why not the others

Remember
Cerebellum crosses twice, so it does not cross at all. Right hemisphere, right arm.

Go deeper

Chronic alcohol damages the anterior superior vermis, giving gait and lower limb ataxia while the arms are relatively spared.

A midline tumour in a child, typically medulloblastoma, presents as truncal ataxia with falls, plus headache from fourth ventricle obstruction.

Snell's Clinical Anatomy by Regions, 11th ed. (Wolters Kluwer, 2024); Gray's Anatomy for Students, 5th ed. (Elsevier, 2023).

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